Prolog Male Fertility- Motility Blend is a
nutritional supplement that helps enhance male fertility and the contents of
this blend have been scientifically validated to improve sperm quality. This
product has been developed to meet the nutritional requirements associated with
male infertility and these levels of specific, fertility-improving nutrients
are not achievable through modification of diet alone.
This product is designed for the male with
impaired sperm quality or elevated DNA fragmentation or varicocele. It has been
developed for the couple where at least one partner is greater than 35 years of
age, as well as those having difficulty conceiving, undergoing fertility
treatments by inseminations or IVF, with unexplained infertility, or recurrent pregnancy
Partial Ingredient List:
Vitamins A, C, E: Help protect sperm and
other cells from reactive oxygen species that cause oxidative stress and
Selenium: A component of enzymes involved in
antioxidant protection and thyroid hormone metabolism. Selenium plays a role in
preventing lipid peroxidation and membrane damage.
Ubiquinol: The reduced form of Coenzyme Q10
that acts as an antioxidant, preventing lipid peroxidation in sperm membranes.
In sperm cells, the majority of CoQ10, an energy promoting agent and
antioxidant, is concentrated in the mitochondria of the midpiece, so that the
energy for movement and all other energy-dependent processes in the sperm cell
also depend on the availability of CoQ10.
Lycopene: Lycopene, the most potent singlet
oxygen quencher of all carotenoids, is a possible treatment option for male
infertility because of its antioxidant properties.
Grape seed extract, Quercetin: Potent
antioxidants that promote normal cell development and guard against oxygen
B vitamins (B2, B12): These key nutrients act
primarily in energy metabolism as coenzymes. They help in the formation,
maturation and motility of sperm.
Zinc: Participates in scores of enzymes in
terms of structural integrity, function and their gene regulation. In the
cytoplasm, zinc is a key component of superoxide dismutase, an enzyme which
advances antioxidant reactions and protects cells from free radical damage.
Folate: As a coenzyme, folate plays an
integral role in DNA synthesis, amino acid synthesis, cell division and the
maturation of red blood cells and sperm cells..
Acetyl-L-Carnitine and L-Carnitine: Amino
acids formed from lysine that shuttle activated fatty acids from cytoplasm into
sperm cell mitochondria. Carnitines
promote cellular energy production and have been proven to help increase sperm
The Scientific Basis:
According World Health Organization
estimates, about one-half of infertility is due to poor semen parameters (sperm
count, motility and morphology) and it has been demonstrated that infertile men
have higher levels of oxidative stress than their fertile counterparts. Due to
the high amounts of polyunsaturated fatty acids found in sperm cell membranes,
the physiological process of sperm cell formation and maturation,
spermatogenesis, is especially susceptible to peroxidation (a form of oxidative
stress in which oxygen atoms are formed leading to the production of
peroxides). Oxidative stress is the imbalance between oxidants (reactive oxygen
species, “ROS”) and the antioxidant system. ROS, or oxygen radicals, such as
hydrogen peroxides, superoxide anions, singlet oxygen and hydroxyl radicals,
are the natural byproducts of oxygen metabolism. Oxygen radicals, however, are
unstable, toxic molecules that contain one unpaired electron. These unpaired
electrons make free radicals highly reactive such that they can react with
lipids, amino acids and DNA/RNA in their vicinity. One free radical can spark a
chain reaction, instantly causing a cascade of new free radicals. In the normal state, the seminal plasma
contains antioxidants which both negate the effects of these ROS and which
protect the sperm cells from oxidative damage. However, during times of
physical or environmental stress, the concentration of ROS can increase
markedly, leading to extensive sperm DNA damage, reduced sperm motility and
defective integrity of the sperm cell membrane.
Oxidative stress can have effects on sperm
DNA and may accelerate testicular programmed cell death (apoptosis). In short,
oxidative stress in the testes may decrease sperm concentration and progressive
motility and may increase the percentage of abnormal forms. These changes are
associated with male sub-fertility and infertility as well as miscarriage.
Inflammation, immature sperm cells, obesity, heat, prolonged sexual abstinence,
varicocele and other environmental factors may also increase oxidative stress.
The protective, buffering antioxidant system
in the semen includes enzymes which neutralize the ROS, as well as other
non-enzyme antioxidants (Vitamins A, C and E, coenzyme Q10, B2, B6, B12,
glutathione). Folic acid, zinc, and selenium also facilitate the antioxidant
system. Human, animal, and cell culture studies have shown that a number of
specific antioxidants lead to improved semen parameters. Nutritional support in
the form of a combination of antioxidants may help guard against ROS and the
associated cellular damage.
Lifestyle modifications may also play a major
role in reproductive health. Whereas, tobacco, marijuana, alcohol and other
toxins can diminish sperm quality, a well-balanced diet and daily aerobic
exercise can improve the semen quality.
Dietary changes alone, however, will not
provide the high level of nutritional support available in this proprietary blend.
The contained, potent antioxidant preparation can help reverse some of the
oxidative stress associated with normal aging, toxins and suboptimal diet. It
takes approximately 74 days for spermatogenesis and various studies in the
reproductive medicine literature have demonstrated that consistent, targeted
nutritional support taken for the appropriate duration may improve sperm
production in men with fertility disorders.
In a systematic review, Ross and coworkers
analyzed the efficacy of antioxidant therapy for male infertility. The
expansive study reviewed various antioxidants including astaxanthin,
carnitines, folic acid, N-acetylcysteine, selenium, vitamin C, vitamin E and
zinc. Of the 3,740 citations reviewed, 16 studies investigated the effect of antioxidants
on semen quality in 1,605 men and an additional 10 studies evaluated the effect
of antioxidants on pregnancy rates. This review concluded that antioxidant
treatment of infertile men reduces oxidative stress in the semen and has more
impact on sperm motility than on concentration and morphology. In addition this
review concluded that antioxidant therapy was associated with a significant
improvement in spontaneous pregnancy rates in 6 of the 10 randomized studies
and a study that analyzed pregnancy rates after assisted reproductive
supplements may have side effects, may affect underlying medical conditions, or
may interact with prescription medications. Therefore, Prolog Health vitamins
and supplements are recommended for use under the direct supervision of your
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